心钠素与脑梗塞的关系（附20例分析）

Relationship between atrial natriuretic polypetide and cerebral infarchon: a analysis of 20 cases

目的探讨心钠素与脑梗塞间的关系，为脑梗塞的防治提供新的理论依据。方法在１Ｗｋ内及２ｗｋ后分别同步采取脑梗塞患者及对照者空腹血浆及ＣＳＦ标本．处理后－２０℃冰冻保存．用γ－计数测定其中ＡＮＰ含量及变化情况．结果正常对照组血及ＣＳＦ中ＡＮＰ含量分别为５０．３７±１７．２９和４７．０８±１６．６０ｎｇ·Ｌ－１．备性脑梗塞（ＩＷｋ内）血浆及ＣＳＦ中ＡＮＰ含量分别为６８．４３±１５．７４和５６．４５±１１．２２ｎｇ·Ｌ－１，明显高于对照组（Ｐ＜０．０１）．结论急性脑梗塞患者血浆及ＣＳＦ中ＡＮＰ含量增高可能与脑梗塞的病理生理机制有关．

Objective To research the relationship between atrial natriuretic polypeptide (ANP) and cerebral infarction in order to provide a new theoretical basis for the prevention and treatment of cerebral infarction.Methods The blood plasma and cerebrospinal fluid (CSF) samPle were collected simultaneously and preserved in - 20℃ in fast Patients with cerebral infarction within one week and after two weeks and in control group The concentration of ANP and its changes were determined with gamma-counter.Results The concentrations of ANP in blood plasma and CSF in control group were 50. 37± 17. 29ng. L-1and 47. 08±16.60ng. 1-1respectively, and that in the acute cerebral infarction (within one week) were respeCtively 68.43t 15.74ng.L-1and 56.45±1 1.22ng. L-1, which were distintly hegher than that in control group.Conclusion The enhancement of concentration of ANP in blood Plasma and CSF in the patients with acute cerebral infarction may be related to pathogenesis of cerebral infarction.