摘要
目的:探讨分子量为60kDa的鲨鱼软骨多糖(SCP)对血脂的影响。方法:建立高脂模型,实验分为正常对照组、阳性对照药组、鲨鱼软骨多糖高、中、低剂量组和高脂模型组;给药15天后,眼静脉取血,测大鼠血清总胆固醇(TC)甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)水平。结果:与高脂模型组比较,鲨鱼软骨多糖中剂量组TC、TG、和LDL均有显著性差异,而HDL无明显变化;鲨鱼软骨多糖低、高剂量组TC、LDL均有显著性差异,而TG、HD无明显变化。结论:分子量为60kDa的鲨鱼软骨多糖有一定的降血脂作用,其机制可能是通过降低血浆中的TC、LDL水平等降血脂。
Objective：To investigate the effect of Shark Cartilage Preparation（SCP） of 60kDa on blood fat. Methods： The model of rat with hyperlipemia was made, the experimental rats were randomly divided into normal group, ChsA group, hyperlipemia model group and SCP groups at varied concentrations . Fifteen days later, the contents of TC,TG.HDL- C and LDL-C were measured. Results ： There were significant differences from the contents of TC.TG and LDL - C between metadosage SCP group and hyperlipemia model group. Homedosage SCP group and hypodosage SCP group were significant differences from hyperlipemia model group in the contents of TC and LDL - C. Conclusion ： SCPof 60kDa could effectively decrease blood fat via decrease the contents of TC and LDL -C.
出处
《辽宁中医杂志》
CAS
北大核心
2006年第6期760-761,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
鲨鱼软骨多糖
总胆固醇
甘油三酯
低密度脂蛋白
高密度脂蛋白
Shark Cartilage Preparation （SCP）
Cholesterol Total （TC）
Glycerolipid Total （TG）
Low Density Lipoprotein（LDL）
High Density Lipoprotein（HDL）
