金海宝口服液对糖尿病大鼠的降糖降脂作用及其机理研究

Effect of Jinhaibao oral liquid on Blood Sugar and Lipids and Its Mechanism in Rats with Diabetes Mellitus

目的探讨金海宝口服液对糖尿病大鼠的治疗作用及其机理。方法利用静脉注射四氧嘧啶制成糖尿病大鼠模型, 给予金海宝口服液进行治疗,治疗同时观测糖尿病大鼠血糖、血脂、抗氧化功能,胰岛素、神经肽Y含量变化。结果同模型组相比,金海宝口服液(大、小剂量组)均可有效降低糖尿病大鼠血糖、血脂,改善大鼠抗氧化功能,并有效升高大鼠胰岛素水平,降低神经肽Y水平。结论金海宝口服液可有效降低糖尿病大鼠的血糖、血脂,且其降糖机制同抗氧化作用,调节神经肽Y功能相关。

Objective To study the therapeutic effect of Jinhaibao Oral Liquid on blood sugar and lipids and its mechanism in the rats with diabetes melitus. Methods Diabetes mellitus was induced by Alloxan in rats. The contents of blood sugar, blood lipids, oxygen--derived free radidieals, insulin and neuropeptide Y were detemined before and after the treatment with J inhaibaooral liquid in the treatment and control groups. Results The concentrations of the blood sugar, blood lipid and neuropeptide Y were significantly lower in the treatment group than those in the control group 2 weeks after the treament and insulin were significant higher in the treatment group than that in theeontol group 2 weeks after the treatment （ P 〈0.01）. Conclusion Jinhaibao oral liquid can decrease the blood sugar and the blood lipid in the rats with diabetes mellitus, and the curative effect may be related to the antioxidative effect and the adjustment of the neuropeptide Y by Jinhaibao.