以关节肌肉皮肤损害为主的嗜酸粒细胞增多症5例报告

A report of 5 cases of hypereosinophilia featured with musculodldetal and skin manifestations

目的:探讨嗜酸粒细胞增多症(hypereosinophilia syhdrome,HES)的关节肌肉皮肤损害的临床特点。方法:回顾性分析5例以关节肌肉皮肤损害为主要临床表现的HES的临床资料及其随访结果。结果:4例为原发性,1例继发于肝吸虫感染,均符合HES的诊断标准。3例以关节肌肉皮肤损害为首发临床表现,2例为确诊HES后随访过程中出现;表现的特点为关节肌肉皮肤损害伴随出现,病变单一出现,非对称性,迁移性发展,对类固醇激素治疗反应良好。随访结果显示,关节肌肉皮肤损害可能是HES其它器官受累的前兆,需要规范的类固醇激素治疗。结论:关节肌肉皮肤损害在HES并非少见,可以是HES的首发临床表现,类固醇激素治疗有效。

Objective： To analyze the clinical featutres of hypereosinophilia with musculoskeletal and skin manifestations. Methods： The clinical features of 5 patients with hypereosinophilia were analyzed retrospectively, and the follow-up data were reported. Results ： Among 5 patients＇4 were diagnosed as idiopathic hypereosinophilia, I was succeeded with clonorchiasis sinensis; 3 cases presented with musculoskeletal and skin manifestations as primary clinical manifestations, the other 2 cases after the diagnosis ; the musculoskeletal and skin manifeststions were characterized by their occurring altogether asymmetrily, migratory presentaion, and good response to steroid therapy. The follow-up data showed that they presented in advance of the other organ involvements and need standardized steroid therapy. Conclusion ： The musculoskeletal and skin manifestations were not rare in hypereosinophilia, they may present as its primary clinical manifestations and have good response to steroid therapy.