毒鼠强慢性中毒的检测及临床意义

Laboratory determination and clinic sense of tetramine chronic poisoning

目的:毒鼠强慢性中毒引起的症状与癫痫很相似,在临床诊断中很容易误诊。本文总结分析了实际工作中遇到的毒鼠强慢性中毒事例,旨在为临床医生在诊断上提供帮助。方法:采用回顾性方法对3起9例毒鼠强慢性中毒患者的检测结果、临床症状与中毒原因进行分析。结果:9例患者中有3例曾因贩卖鼠药而中毒的,6例为被多次小剂量投毒引起的,前者因害怕承担法律责任故意隐瞒接触史,后者的病因较为隐蔽。通过症状表现、现场调查和实验室检测手段进行了确证为毒鼠强慢性中毒。结论:在排除遗传家族史、脑外伤以及其他引起中枢神经紊乱的药物外,遇到不明原因癫痫样症状进行毒鼠强的检测,可以作为临床诊断的辅助依据。

The symptoms of tetramine chronic poisoning are similar to epilepsy , so it is easier to be misdiagnosed . This article aims to provide some help for clinic doctors in diagnosis. Methods ： We analysed retrospectively 9 tetramine chronic poisoning patients, lab results and poisoning course and syndromes Results ： Three cases were poisoned because they sold rodenticides for a long time and were delayed to be treated correctly out of hinding their touching history. Six cases were caused intentionally by criminal with low dose of tetramine. All the biological samples were positive through lab detection in Zhengzhou CDC. Conclusion ： It is necessary and important to do lab detection of tetramine if there is eleptiform without unambiguous causes after excluding heredity factor and brain trauma and medicines leading to functional disorder of central nerve.