冠心病患者血清新蝶呤浓度的变化及其意义

Changes and significance of serum neopterin concentrations in patients with coronary heart disease

目的:探讨不同类型的冠心病与血清新蝶呤(Npt)水平的相关性。方法:对60例冠心病患者,分为稳定性心绞痛(SAP)、不稳定性心绞痛(UAP)、急性心肌梗死(AMI)3组,每组各20例,测定其Npt浓度以及C-反应蛋白(CRP)和心肌肌钙蛋白I(CTnI)等。结果:AMI及UAP组的血清Npt浓度显著高于SAP组(P<0.001),AMI组的血清Npt浓度亦高于UAP组(P<0.05),AMI患者的Npt水平与CRP呈正相关性(r=0.482,P=0.032),而与CTnI不相关(r=0.205,P=0.177)。结论:血清中Npt浓度的升高与急性冠脉综合征(ACS)有关,可能是不稳定斑块及ACS的预测因子。

Objective： To explore the relationship between serum neopterin levels and different types of coronary heart disease. Methods： Serum neopterin concentrations and C-reaction protein （CRP） and myocardial troponi （CTnI） were measured in 60 patients with coronary heart disease, including stable angina pectoris （SAP）, unstable angina pectoris （UAP） and acute myocardial infarction （AMI）.There were 20 cases in each group. Results： Serum neopterin levels in the AMI group （19.36±5.62） and UAP group （16.55±6.33） were significantly higher than those in the SAP group （12.10± 3.81） （all P〈0.001）. Also, serum neopterin levels in AMI group were higher than those in the UAP group （P〈0.05）. The levels of neopterin in AMI patients were positively correlated with CRP （r=0.482, P=0.032） and were not correlated with CTnI （r=0.205, P=0.177）. Conclusion： High neopterin levels was correlated with acute coronary syndromes （ACS）. It may be a predictor of vulnerable plaques and ACS.