0.3%加替沙星和0.3%环丙沙星治疗细菌性角膜炎的疗效观察

Comparison of topical gatifloxacin 0.3% and cipro-floxacin 0.3% for the treatment of bacterial keratitis

PURPOSE: To compare the bacteriologic and clinical efficacy of gatifloxacin and ciprofloxacin for the treatment of bacterial keratitis. DESIGN: Prospective, randomized clinical trial. METHODS: A total of 104 eyes of 104 patients with bacterial keratitis seen at a tertiary eye-care center were randomized to treatment with gatifloxacin 0.3%eyedrops (GAT group, 50 eyes) or ciprofloxacin 0.3%eyedrops (CIP group, 54 eyes). Patients and the treating physician were masked to the antibiotic being used. Main outcome measure studied was healing of the ulcer. Patients lost to follow-up before complete healing were excluded from further analysis. RESULTS: A significantly higher proportion of ulcers in the GAT group exhibited complete healing compared with those in the CIP group (39 eyes 95.1% vs 38 80.9% ; P=.042). Gatifloxacin demonstrated a significantly better action than ciprofloxacin against gram-positive cocci in vitro (P < .001), and the percentage of ulcers caused by these pathogens that healed in the GAT group was significantly better than in the CIP group (P=.009). Mean time taken for healing of ulcer and the efficacy against gram-negative bacteria did not significantly differ between the two groups. CONCLUSIONS: Gatifloxacin had a significantly better action against gram-positive cocci both in vitro and in vivo when compared with ciprofloxacin. In view of these organisms being the leading cause of keratitis worldwide, gatifloxacin may be a preferred alternative to ciprofloxacin as the first-line monotherapy in bacterial keratitis.

PURPOSE： To compare the bacteriologic and clinical efficacy of gatifloxacin and ciprofloxacin for the treatment of bacterial keratitis. DESIGN： Prospective, randomized clinical trial. METHODS： A total of 104 eyes of 104 patients with bacterial keratitis seen at a tertiary eyecare center were randomized to treatment drops （GAT group, 50 eyes） drops （CIP group, 54 eyes） physician were masked to the outcome measure studied was with gatifloxacin 0. 3% eyedrops （GAT group, 50 eyes） or ciprofloxacin 0. 3% eyedrops （CIP group, 54 eyes） . Patients and the treating physician were masked to the antibiotic being used. Main outcome measure studied was healing of the ulcer. Patients lost to follow-up before complete healing were excluded from further analysis. RESULTS： A significantly higher proportion of ulcers in the GAT group exhibited complete.