亚临床甲减患者血清总同型半胱氨酸水平的临床研究

Clinical Study of Total Serum Homocysteine Level in the Patients with Subclinical Hypothyroidism

目的探讨亚临床甲减患者血清tHcy的变化及与血清总胆固醇、TSH、FT4水平的相关关系。方法应用酶免技术测定60例亚临床甲减患者与40例正常对照组血清tHcy的浓度,同时用生化和化学发光法测定血清总胆固醇和TSH、FT4水平,并进行相关性分析。结果亚临床甲减组血清tHcy水平高于正常对照组,且tHcy与胆固醇、TSH水平呈正相关,与FT4水平呈负相关。结论血清tHcy可作为亚临床甲减并发心血管疾病的危险因素,对亚临床甲减预后的判断起一定指导作用,同时可能对判断甲状腺功能有辅助作用。

Objective To investigate the changes of the serum total homocysteine（tHcy） levels in the patients with subclinical hypothyroidism and the relationship between tHcy and cholesterol,TSH as well as free T4. Methods Sixty patients with subclinical hypothyroidism and 40 control subjects were recruited to the study. The tHcy was measured using ELISA;Serum cholesterol was detected with biochemical methods;Serum TSH and free T4 were measured with chemiluminescence. Results The serum tHcy levels were higher in patients with subclinical hypothyroidism than that in control subjects. The tHcy was positively correlated with cholesterol and TSH, but showed a inverse associateion with free T4. Conclusion The increase of tHcy in subclinical hypothyroidism may be a possible risk factor of vascular occlusive disease,and the level of tHcy may be an assistant factor to determine thyroid function.