人胃肠粘膜乙醇脱氢酶的分布

Alcohol dehydrogenase distribution in human gastrointestinal mucosa

目的研究乙醇脱氢酶(ADH)在人胃肠道不同部位含量差异的意义。方法采用分光光度法检测人胃体、胃窦(n=31)、十二指肠降段(n=31)、升结肠及直肠粘膜(n=38)ADH。结果 ADH在胃体、胃窦、十二指肠降段、升结肠及直肠粘膜中的含量分别为0.86,0.84,1.16,1.18和1.27 nmol/min·g。十二指肠及结肠粘膜中ADH含量明显高于胃粘膜(P<0.05)。直肠粘膜含量最高。结论 ADH在胃肠道不同部位含量有差异。结果有助于阐明第一关卡代谢的部位及长期饮酒者易患直肠癌的机制。

AIMS To investigate the significance of levels of alcohol dehydrogenase(ADH) in different sites of gastrointestinal mucosa in humans. METHODS ADH levels were measured by spectrophotometric method in human biopsy samples of gastric body and antrum (n=31), second part of duodenum (n=31), ascending colon and rectum (n=38). RESULTS The levels of ADH were 0.86, 0.84, 1.16, 1.18 and 1.27 nmol/min·g in gastric body and antrum, second part of duodenum, ascending colon and rectum, respectively. The levels of ADH were higher in duodenum and large intestine than in gastric body and antrum(P<0.05). Its highest level was found in rectum. CONCLUSIONS ADH levels are different in different sites of gastrointestinal tract. It might help to reveal the origin of first pass metablism of ethanol and the reason why risk of rectal cancer increased following chronic ethanol ingestion.