p27和CyclinE的阳性表达与宫颈癌临床病理特点的关系

Correlation of p27 and Cyclin E expression with the clinical and pathological features of cervical carcinoma

目的探讨p27和CyclinE在宫颈癌组织中的表达及其与肿瘤临床病理特点的关系。方法采用免疫组化SP法检测85例宫颈癌组织标本中p27及CyclinE蛋白,分析它们与肿瘤临床病理特点的关系。结果85例宫颈癌中,p27的阳性表达率为28.2%,高分化宫颈癌中p27的阳性表达率明显高于低分化者(P<0.01);有淋巴结转移的宫颈癌中p27的阳性表达率明显低于无淋巴结转移者(P<0.05)。CyclinE的阳性表达率为76.5%,低分化宫颈癌中CyclinE的阳性表达率明显高于高分化者(P<0.01)。p27与CyclinE的表达之间无明显相关关系(P>0.05)。结论p27的表达降低与宫颈癌的恶性进程和侵袭转移相关,CyclinE的高表达提示宫颈癌的恶性程度。综合分析p27和CyclinE的表达,可以评价宫颈癌的恶性程度和预后。

Objective：To investigate the expression of p27 and Cyclin E in cervical carcinoma and it＇s correlation with the clinical and pathological features. Methods： Expression of p27 and Cyclin E in 85 cases of cervical carcinoma were detected by immunohistocbemistry assay. In addition, relationship between expression of p27 and Cyclin E and clinic -pathologic features was studied. Results： Within 85 cases of cervical carcinoma, expression rate of p27 was 28.2%. It＇s expression in higher differentiated cervical carcinoma is significantly higher （ P 〈0.01 ） ; A significant higher expression in the cases without lymph node metastasis was also observed. Expression rate of Cyclin E was 76.5%. The expression of Cyclin E was significantly higher in lower differentiated cervical carcinoma （ P 〈0.01 ）. There was no correlation between the expression of p27 and Cyelin E （ P 〉 0.05 ）. Conclusion ： Down regulation of p27 expression has close relationship with the grade of cervical carcinoma and lymph node metastasis. Up regulation of cyclin E expression correlates with its grade, p27 and Cyclin E expression can estimate the malignancy degree of cervical carcinoma and prognosis.