Role of discs large homolog 5

在 2004，在磁盘的基因变化的一个协会大相当或相同的事物 5 (DLG5 ) 有煽动性的肠疾病(IBD ) 的基因在二件大欧洲学习样品被描述。新奇 IBD 危险性基因引发在 CD 和 IBD 上调查它的效果分别地，在 Crohn 疾病的原因论有关发现的起始的协会和它的角色的有效性导致争论调查结果和进行中的讨论的大量的研究的 DLG5 的起始的报告。这评论试图总结知识的当前的状态并且把报导调查结果放在复杂疾病的当前的概念的上下文。这象基因基因和基因环境相互作用一样包括在不同人口之间的统计力量，显型差别和基因异质的方面。

In 2004, an association of genetic variation in the discs large homolog 5 （DLG5＇） gene with inflammatory bowel disease （IBD） was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions.