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Aspart与正规人胰岛素应用胰岛素泵控制血糖的疗效比较 被引量：12

Comparison of therapeutic efficacy between Aspart and regular human insulin delivered by insulin pump
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摘要 选择21例应用预混人胰岛素Novolin 30R治疗血糖控制欠佳的1型和2型糖尿病患者,用胰岛素泵交叉应用相同剂量的速效人胰岛素类似物Aspart与正规人胰岛素NovolinR控制高血糖,比较两种药物应用期间全天毛细血管血糖谱,发现Aspart在控制空腹血糖、餐后血糖及全天平均血糖均较后者疗效为佳。 Twenty-one patients with diabetes mellitus received rapid-acting human insulin analogues Aspart or regular human insulin NovolinR therapy by insulin pump and 8-time points capillary glucose assays. Lower blood glucose levels were more readily achievable with Aspart than with NovulinR.
作者 毕宇芳 宁光 孙首悦 周莹霞 洪洁 刘建民 赵咏桔 李小英 王卫庆
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病临床医学中心
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第3期266-267,共2页 Chinese Journal of Endocrinology and Metabolism
基金 上海市教委重点学科建设经费资助项目(2001) 上海市卫生局重大课题基金(2001)
关键词 ASPART 正规人胰岛素 胰岛素输注系统 糖尿病 Aspart Regular human insulin Insulin infusion systems Diabetes mellitus
分类号 R587.1 [医药卫生—内分泌] R977.15 [医药卫生—药品]
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参考文献10

  • 1Hermansen K, Fontaine P, Kukolja KK, et al. Insulin analogues(insulin detemir and insulin espart) versus traditional human insulins(NPH insulin and regular human insulin) in besal-bolus therapy for patients with type 1 diabetes. Diabetologia, 2004,47:622-629.
  • 2Radermecker RP, Scheen AJ. Continuous subcutaneous insulin infusion with short-acting insulin analogues or human regular insulin: efficacy,safety, quality of life, and cost-effectiveness. Diabetes Metab Res Rev,2004,20 : 178-188.
  • 3郭瑞金,薛元明,施珏,蔡玮.人胰岛素类似物(Insulin Aspart)持续皮下注射治疗2型糖尿病[J].中华内分泌代谢杂志,2005,21(3):278-279. 被引量：24
  • 4Heller SR. Insulin analogues. Curr Med Res Opin, 2002, 18 (Suppl 1):840-47.
  • 5Bretzel RG, Amolds S, Medding J, et al. A direct efficacy and safety comparison of insulin aspart, human soluble insulin, and human premix insulin (70/30) in patients with type 2 diabetes. Diabetes Care, 2004,27 : 1023-1027.
  • 6Bott U, Ebrabim S, Hirschberger S, et al. Effect of the rapid-acting insulin analogue insulin espart on quality of life and treatment satisfaction in patients with type 1 diabetes. Diabet Med, 2003,20:626-634.
  • 7Danne T, Aman J, Schober E, et al. A comparison of postprandial and preprandial administration of insulin espart in children and adolescents with type 1 diabetes. Diabetes Care, 2003,26:2359-2364.
  • 8Ceriello A, Cavarape A, Martinelli L, et al. The post-prandial state in Type 2 diabetes and endothelial dysfunction: effects of insulin aspart.Diabet Meal, 2004,21:171-175.
  • 9Plank J, Wutte A, Brunner G, et al. A direct comparison of insulin aspart and insulin lispro in patients with type 1 diabetes. Diabetes Care, 2002,25:2053-2057.
  • 10Heller SR, Colagiuri S, Vaaler S, et al. Hypoglycaemia with insulin aspart: a double-blind, randomised, crossover trial in subjects with type 1 diabetes. Diabet Med, 2004,21:769-775.

二级参考文献3

  • 1Greenspan FS, Strewler GJ. Basic Clinical, Endocrinology (5th ed). Appelton ﹠Lange,1999,666.
  • 2Ottesen JL, Nilsson P, Jami J, et al, The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model.Diabetologia, 1994,37:1178-1185.
  • 3Home PD, Lindholm A, Hylleberg B, et al . Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group. Diabetes Care,1998,21:1904-1909.

共引文献23

同被引文献94

引证文献12

二级引证文献81

中华内分泌代谢杂志
2006年 第3期

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