二甲双胍和饮食因素对糖尿病小鼠骨骼肌AMPK活性的影响

Effect of metformin and low-fat diet on the activity of AMP-activated protein Idnase in diabetic mice

将2型糖尿病KK-Ay小鼠分为二甲双胍/高脂饮食、二甲双胍/低脂饮食、高脂饮食和低脂饮食4组,通过测定骨骼肌中腺苷酸活化蛋白激酶(AMPK)活性,发现二甲双胍和低脂饮食均可使AMPK活性增加,二者不存在累加效应。

KK-Ay mice with type 2 diabetes were divided into mefformin plus high-fat diet, mefformin plus low-fat diet, high fat diet alone and low fat diet alone groups. AMP-activated protein kinase （AMPK） activity was measured in skeletal muscle. The results showed that mefformin and low-fat diet were able to increase AMPK activity. However, no additive effect on AMPK activity by mefformin and low-fat diet was found.