期刊文献+

氯沙坦防治肝硬化腹水复发临床研究

下载PDF
导出
摘要 目的观察氯沙坦防治肝硬化失代偿期腹水复发的治疗效果,探讨其作用机制。方法将96例肝硬化失代偿期腹水形成患者随机分为治疗组与观察组,两组病人均予常规治疗,治疗组加用氯沙坦50 mg/d,疗程一年,追踪观察腹水复发情况。结果治疗组一年内复发率明显低于对照组,(P<0.01)。结论氯沙坦可减缓肝硬化患者腹水复发。
作者 李志庆
出处 《湘南学院学报(医学版)》 2006年第2期41-42,共2页 Journal of Xiangnan University(Medical Sciences)
  • 相关文献

参考文献6

二级参考文献15

  • 1[1]Garcia-Tsao G.Current management of the complication of the cirrhosis and portal hypertension.Variceal hemorrhage,ascites and spontaneous bacterial peritonitis.Gastroenterol,2001,120(4):726-748
  • 2[2]Kamath PS,Tyce GM,Miller VM,et al.Endothelin-1 modulate intrahepatic resistance in a rat model of noncirrhotic portal hypertension.Hepatology,1999,30(3):401-407
  • 3[3]Rockey D.The cellular pathogenesis of portal hypertension.Stellate cell contractility.Endothelin and nitric oxide.Hepatology,1997,25(1):2-5
  • 4[4]Chan CC,Wang SS,Lee FY,et al.Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats.Hepatology,2001,33(5):816-820
  • 5[5]Arroyo V,Guevara M,Gines P.Hepatorenal syndrome in cirrhosis:Pathogenesis and treatment.Gastroenterology,2002,122(8):1658-1676
  • 6[6]Rouyon BA,Montano AA,Akriviadis EA,et al.The serum ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites.Ann Intern Med,1992,117(2):215-220
  • 7[7]Rocky DC,Chang JJ.Reduced nitric oxide production by endothelial cells in cirrhotic rat liver endothelial dysfunction in portal hypertension.Gastroenterology,1998,114(2):344-351
  • 8[8]Wong F,Liu P,Blendis L.The mechanism of improved sodium hemeostatis of low-dose losartan in preascitic cirrhosis.Hepatology,2002,45(6):1449-1458
  • 9[9]Martin PV,Gines P,Schrier RW.Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis.N Engl J Med,1998,339(1):533-541
  • 10[10]Villa GL,Barletta G,Pantalio P,et al.Hemodynamic,renal,and endocrine effects of acute inhibition of nitric oxide synthase in compensated cirrhosis.Hepatology,2001,34(1):19-27

共引文献14086

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部