摘要
本研究利用-κ阿片受体激动剂U50488H预处理(U50488Hpretreatment,UP)大鼠,在离体Langendorff灌流心脏和缺血/复灌模型上观察-κ阿片受体激动剂诱发的延迟性心肌保护作用,研究结果表明U50488H预处理大鼠24h后,可明显改善心肌缺血后的复灌期内LVEDP的抬高,以及LVDP和±dP/dtmax的下降(P<0.05);其作用可被κ阿片受体选择性拮抗剂Nor-binaltorphimine(nor-BNI)所阻断。结论:刺激-κ阿片受体诱导了延迟性心肌保护作用。
The aim of the present studies was to determine whether U50488H, a specific K-opioid receptor agonist, could induce dalayed cardioprotecfion against myocardical ischemia / reperfusion injury and to explore the underlying mechanisms. Isolated perfused rat hearts were subjected to 30 rain of ischemia followed by 120 rain reperfusion. Left ventricular end-diastolic pressure （LVEDP）, left ventricular developed pressure （LVDP） and maximal velocity of contraction and relaxation （±dP/dtmx） were improved when U50488H was administered 24h before ischemia （P〈0.05）. In conclusion, K-opioid receptor stimulation could induce delayed cardioprotection against myocardial ischemia and reperfusion.
出处
《金华职业技术学院学报》
2006年第3期76-79,共4页
Journal of Jinhua Polytechnic
关键词
K-阿片受体
心肌缺血
复灌
K-opioid receptor
, myocardial ischemia
reperfusion
