银杏达莫治疗早期糖尿病肾病20例

Clinical Study of Ginkgo-Dipyridamole in the Treatment of 20 Patients with Early Diabetic Nephropathy

目的探讨银杏达莫治疗早期糖尿病肾病的疗效及其作用机制。方法40例早期糖尿病肾病患者,随机分为治疗组和对照组各20例,治疗组给予0.9%氯化钠注射液250mL+银杏达莫注射液30mL静脉滴注;对照组给予0.9%氯化钠注射液250mL+维生素C1g静脉滴注,疗程均为3周。观察两组患者治疗前后空腹血糖(FBG)、餐后2h血糖(PBG2h)、糖化血红蛋白(HbAlC)、收缩压(SBP)、舒张压(DBP)、24h尿清蛋白、尿素氮(BUN)、肌酐(Cr)、胆固醇(CHO)、三酰甘油(TG)、24h尿量变化情况。结果治疗组24h尿清蛋白定量、CHO和TG水平与治疗前比较显著下降(P<0.05),与对照组比较亦显著下降(P<0.05)。治疗组Cr、BUN与治疗前比较有所下降,与对照组比较亦有所下降,但差异均无显著性(P>0.05)。治疗组24h尿量与治疗前比较有所增加,与对照组比较也增加,但差异均无显著性(P>0.05)。结论银杏达莫可以降低早期糖尿病肾病患者尿清蛋白及血脂水平,对糖尿病肾病有治疗作用。

Objective To explore the therapeutic effect and mechanism of the ginkgo-dipyridamole injection （ EGb761 ） in the treatment of the early diabetic nephropathy （DN）. Methods Forty patients with early DN were randomly divided into treatment group （n = 20） and control group （n = 20）. The patients in treatment group were treated with treatment 30 mL every day for 3 weeks,while those in control group,with vitamin C 1 g every day for 3 weeks, The changes in fasting blood glucose （FBG） ,postprandial 2 h blood glucose （PBG2h） ,glycosylated hemoglobin （ HbA1 C） ,24-hour urinary albumin （ U-A1b/ 24h ）, blood urea nitrogen （ BUN ）, creatinine （ Cr）, triglyceride （ TG）, and cholesterol （ CHO ）, and 24-hour urinary output were observed before and after treatment. Results After three weeks of treatment, the levels of U-A1b/24 h, TG and CHO were significantly decreased in treatment group as compared with those before treatment and control group （ P 〈 0.05 ）. The levels of Cr, BUN and 24-hour urinary output were improved, but with no statistically significant difference （ P 〉 0.05 ）. Conclusion Ginkgo-dipyridamole injection has effects of decreasing the levels of U-A1b/24 h and blood lipids with the rapeutic effects on the early DN.