摘要
使用溶剂热法,吡啶-2-甲醛缩氨基硫脲与Co(C lO4)2.6H2O反应制备了Co(Ⅲ)配合物[Co(C7H7N4S)2](C lO4),并用元素分析、红外光谱和紫外光谱对配合物进行表征。采用SRB法试验了配体和配合物对体外口腔黏膜癌细胞(KB)的敏感性,结果表明浓度为0.16 m g/L时,配合物对细胞杀伤力大于配体,金属与配体作用可能具有加合作用。
Complex [Co（C7H7N4S）2]（ClO4） was prepared by means of the reaction of Co （ClO4）2 · 6H2O and Schiff base ligand derived from pyridine-2-carboxaldehyde and thiosemicarbazide using hydro（solv） thermal methods, which was characterized by elemental analysis, UV-vis, and IR spectrum. The test showed that the anticancer activity of the complex against KB in the concentration of 0. 16 mg/L was stronger than that of the ligand,which indicated that there existed adduction effect in the complex case.
出处
《广西师范大学学报（自然科学版）》
CAS
北大核心
2006年第2期64-67,共4页
Journal of Guangxi Normal University:Natural Science Edition
基金
广西科技攻关项目(桂科攻0429001)
广西高校百名中青年学科带头人资助项目
高等学校优秀青年教师教学科研奖励计划资助项目
教育部新世纪优秀人才支持计划资助项目(NECT-04-0836)
