摘要
目的探讨晚期卵巢上皮性癌新辅助化疗的疗效。方法CP方案为环磷酰胺(CTX)0.8 g加入生理盐水40 m l内静推,第1天,顺铂(DDP)100 mg/m2腹腔内注入,第1天;NP方案为诺维本40 mg加入生理盐水125 m l内静滴,第1、8天,DDP 100 mg/m2腹腔内注入,第1天;疗程间隔3周。结果30例Ⅲ期以上患者经2个疗程新辅助化疗后26例达到满意的肿瘤细胞减灭术,有效率达86.6%。结论晚期卵巢上皮性癌经新辅助化疗可控制腹水,大块病灶缩小,与周围脏器的粘连松动,便于手术切净。
Objective To investigate the therapeutic effect of neoadjuvant chemotherapy on epithelial ovarian cancer. Methods CP or NP regimens were used. CP regimen involved CTX 0.8 g in 40 ml normal saline by iv injection and DDP 100 mg/m^2 by abdominal infusion on the first day. NP regimen involved NVB 40 mg in 1：25 ml normal saline by iv injection on the first and the eight days ,and DDP 100 mg/m^2 by abdominal infusion on the first day. The interval of therapy lasted 3 weeks. Results Thirty patients with stage Ⅲ and stage Ⅳ cancers received two courses of the above neoadjuvant chemotherapy. Of them,26 got satisfactory control of cancer, accounting for 86.6%. Conclusion Neoadjuvant chemotherapy for advanced epithelial ovarian cancer can control the ascites, decrease the tumor size and loosen the adhesion with other organs for facilitating operation.
出处
《中国肿瘤临床与康复》
2006年第3期239-240,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
