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肝纤维化发生机制的研究进展 被引量:5

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作者 龙云 唐红
出处 《肝脏》 2006年第3期203-205,共3页 Chinese Hepatology
基金 国家杰出青年基金资助(30325036)
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参考文献16

  • 1Kato J, Sato Y, Inui N, et al. Ethanol induces transforming growth factor-a expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells. Alcoholism: Clin Experiment Res, 2003,27 : 585-635.
  • 2Guluvov MV, Stoyanov HD, Juliano VAE, et al. Immunohistochemical detection of conagem type Ⅲ and Ⅳ in relation with transformation of Ito cells in liver sinusoids of patients with reactive biliary hepatitis. Acta Histochem, 1999, 101: 213-222.
  • 3Xu L, Hoi AY, Albanis E, et al. Human hepatic stellate cell lines, Lx-1 and Lx-2:new tools for analysis of hepatic fibrosis. Gut ,2005,54: 142-151.
  • 4Li J J, Hu WM. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stenate cells. Life Sci, 2003,73: 1083-1096.
  • 5Sokol RJ. Liver cell injury and fibrosis. Pediat Gastroenterol Nutr, 2002,35 : S7-S10.
  • 6陈云,杜建,王玉海.慢性乙型肝炎血浆内毒素与肝纤维化指标及肝脏病理的关系[J].临床肝胆病杂志,2005,21(1):3-4. 被引量:14
  • 7Keynolds WF, Patel K, Pianko S. A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection, Genes Immun, 2002,3 : 345-349.
  • 8Saito JM, Bostick MK, Campe CB, et al. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. Hepatol Res, 2003, 25:180-191.
  • 9Adachi T, Togashi H, Suzuki A, et al. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology,2005,41 : 1272-1281.
  • 10Borkham-kamphorst E, ston D, Gressner AM, et al. Inhibitory effect of soluble PDGF-β receptor in culture-activated hepatic stenate cells. Biochem Bioph Res Communicat, 2004, 317 : 451-462.

二级参考文献38

  • 1Li D, Friedman SL. Liver fibrogenesis and the rote of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol,1999, 14:618-33.
  • 2Paradis V, Dargere D, Vidand M, et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatotogy, 1999, 30:968-76.
  • 3Saite B, Knittel T, Matthes N, et al. CD95/CD95 L - mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepaic stellate cell proliferation during hepatic tissue repair. Am J Pathol, 1997, 151:1265-72.
  • 4Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest, 1998,102:538-49.
  • 5Iredale JP. Tissue inhibitors of metalloproteinases in liver fibrosis. Int J Biochem Cell Biol, 1997, 29:43-54.
  • 6Saite B, Matthes N, Knittel T, et al. Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells. Hepatology, 1999, 30:196-202.
  • 7Trim N, Morgan S, Evans M, et al. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am J Pathol, 2000,156:1235-43.
  • 8Svegliati - Baroni G, Ridolfi F, Di Sario A, et al. Insulin and insulin-like growth factor- 1 stimulate proliferation and type Ⅰ collagen accumulation by human hepatic stellate cells: differential effect on signal transduction pathways. Hepatology, 1999, 29:1743-51.
  • 9Fibbi G, Pucci M, Grappone C, et al. Functions of the fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet- derived growth factor. Hepatology, 1999, 29:868-78.
  • 10Issa R, Williams E, Trim N, et al. Apoptosis of hepatic stellate cells:involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut, 2001, 48:548-57.

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