孕期血清IL-6与胎膜早破、绒毛膜羊膜炎相关性研究

目的探讨孕妇血清白细胞介素-6（IL-6）与胎膜早破及绒毛膜羊膜炎的关系：方法选择2004年1月～2005年3月在广州花都区人民医院分娩的胎膜早破孕妇50例和正常孕妇50例，采用ELISA法测定血清中IL-6水平，分娩时取胎盘胎膜组织作病理检查。结果胎膜早破孕妇血清中IL-6水平明显高于对照组（P〈0.05），并随着破膜时间延长，孕妇血清IL-6水平有增加趋势；有绒毛膜羊膜炎者血清IL-6水平高于无绒毛膜羊膜炎者及对照组（P〈0．05）。结论血清IL-6水平升高对诊断胎膜早破合并绒毛膜羊膜炎有重要意义。

Objective To explore the relationship of IL -6 ,premature rupture of fetal membranes and ehorial amnionitis. Methods Using enzyme linked immunosorbent assay （ ELISA）, IL -6 levels in maternal blood were detected in 50 cases of premature rupture of fetal membranes,50 normal full - termed pregnant women as controls. Results In premature rupture of fetal membranes group, IL - 6 levels in materal blood were significantly higher than in normal full - termed pregnant women group （ P 〈 0.05）. IL - 6 levels in maternal blood showed a tendency of increasing with time grolongation after rupture of membranes. In the cases of chorial amnionitis, the IL - 6 levels in maternal blood were dramatically higher than those without chorial amnionitis （ P 〈 0.05 ）. Conclusions Detection of IL - 6 levels in maternal blood could play an important role in diagnosis of premature rupture of fetal membranes and ehorial amnionitis.