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普伐他汀对急性心肌梗死的疗效及抗炎作用 被引量：3

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摘要 目的研究普伐他汀对急性心肌梗死(AMI)治疗作用及其机制。方法将体重1．5-2．5 kg的成年兔24只随机分为对照组(A组),普伐他汀组(B组)两组,建立AMI模型并给予相应的干预,作术后6 h血液学观察,4 d时分别作血液、血清、血流动力学、大体形态测量及组织学的观察,4周时测量瘢痕厚度。结果B组与A组比较,6 h,4 d及4周时白细胞数明显下降(P<0．05),术后4 d一氧化氮(NO)两组差异无显著性(P>0．05),心房钠尿肽(ANP)、丙二醛(MDA)、左室功能测定值(STI)、左室舒张未压(LVEDP)、梗死面积均明显下降(P<0．05)。4周时B组瘢痕厚度较A组变薄(P<0．05),组织学检查显示A组梗死区术后4 d坏死心肌组织结构消失,中性粒细胞大量浸润,B组白细胞浸润程度与A组无明显差异,但B组梗死区中有少许坏死心肌组织。在B组梗死区边缘可见有带细胞核的心肌细胞结构,可能是活的心肌细胞岛,但A组少见。结论证实普伐他汀对AMI短期使用后疗效显著,其抗炎作用在此过程中的意义值得关注。
作者 王湛 黄晓忠 杨欣国
机构地区 广东省深圳市罗湖区人民医院心内科 第四军医大学唐都医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2006年第7期962-964,共3页 Guangdong Medical Journal
关键词 普伐他汀 心肌梗塞 急性 炎症
分类号 R542.22 [医药卫生—心血管疾病] R972.6 [医药卫生—药品]
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参考文献10

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同被引文献33

  • 1罗伟仁,陈小毅.环氧化酶-2与肿瘤的关系[J].肿瘤防治研究,2006,33(1):62-64. 被引量：18
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引证文献3

二级引证文献8

广东医学
2006年 第7期

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