利用Mitsunobu反应合成芳基吡啶烷基醚(英文)

Synthesis of Aryl Pyridylalkyl Ethers by Mitsunobu Reaction

在室温下,以取代苯酚1a-b和吡啶烷基醇2a-d为原料通过Mitsunobu反应合成了相应的芳基吡啶烷基醚,反应收率为45%￣70%,反应物2和1之比为1.11∶(摩尔比)。结果表明当酚的6-位取代基为甲氧基时,产物的收率比6-位上没有取代基时的收率高;溶剂对反应收率的影响不大。并用1H NMR、13C NMR和MS等对产物的结构进行了测定。

A few of aryl pyridylalkyl ethers were synthesized by Mitsunobu reaction from substituted phenols la-b and pyridyl alcohols 2a-e at room temperature in 45%-70% yields. The ratio of 2 to 1 is 1.1 ： 1 （mol/mol）. The yield of the reaction of 2-iodo-6-phenol was higher than those obtained with 2-iodo-phenol, and the solvent has little effect on the yield of the reaction. The structure of the products were assigned with ^1H NMR, ^13C NMR and MS.