甲位戊基桂醛的合成研究

Synthesis of α-Amyl Cinnamaldehyde

以苯甲醛和正庚醛为原料,乙二醇为溶剂,在氢氧化钾催化作用下羟醛缩合合成甲位戊基桂醛。实验研究了不同溶剂、催化剂用量、苯甲醛和正庚醛的摩尔比、反应时间、乙二醇用量等因素对反应结果的影响,得出了优化工艺条件:催化剂用量为正庚醛质量的17.5%,苯甲醛和正庚醛的摩尔比为1.5∶1,反应时间为6 h,乙二醇用量为190.0g,收率达到90.5%(以正庚醛计),副产物戊基壬烯醛含量小于1.0%。

α-Amyl cinnamaldehyde was synthesized from benzaldehyde and n-heptanal by aldol condensation with catalyst potassium hydroxide in solvent ethylene glycol. The effects of different solvents, catalyst amount, mole ratio of benzaldehyde and n-heptanal, reaction time and ethylene glycol amount on the yields of α-amyl cinnamaldehyde were investigated. The optimal condition was as follows ： w （cat） = 17.5% （n-heptanal）, n （benzaldehyde） ： n （n-heptanal） = 1.5 ： 1, reaction time 6 h, ethylene glycol 190.0 g. The yield of α-amyl cinnamaldehyde based on n-heptanal was more than 90.5%, and the amount of byproduct amyl nonenal was less than 1.0%.