四川省3例人禽流感分析

Analysis of Three Avian-human Influenza Cases in Sichuan Province

目的分析四川省3例人禽流感病例特点,为防治提供科学依据。方法按照《人禽流感流行病学调查方案》,对病例进行个案调查,调查发病经过、治疗情况,实验室检测,可能的感染来源,传播途径及暴露因素等。结果3例人禽流感病例初期临床表现主要为流感样症状,2例病例的气管分泌物分离出禽流感病毒H5N1,1例病例的气管分泌物禽流感病毒H5N1核酸阳性,3例病例咽拭子样核酸均为阴性。1例病例未发现明确的病死禽接触史;2例虽有明确的病死家禽接触史,但死禽未被证实感染禽流感病毒。结论3例病例均为实验室确诊病例;应尽量采集患者的气管分泌物样进行检测;对人禽流感病例的诊断不能完全依据禽流感疫情存在与否;人禽流感的感染来源、传播途径和影响因素等问题尚待进一步研究。

Objective To analyze the feature of three Avian - human Influenza cases in Sichuan province, and to provide scientific reference for the prevention and control. Methods According to the epidemiological investigation plan of Avian - human Influenza, case investigation were made for all these cases, which including the process of falling ill, treatment, laboratory detection, possible infection source, transmission route, risk factors, ect. Results One of these cases was not exposed to the dead or illed fowl, but the others were exposed to. There was no evidence to manifest that the dead or ill fowl were infected with Avian Influenza; symptom of the cases looked like flu in incipience; the Avian Influenza virus H5N1 was detected from the samples of trachea excrete of two cases, RNA testing of the trachea excrete sample of the other case was positive. RNA testing of the pharynx sample of three cases were negative. Conclusions Three cases are pathogen confirmed patients. It is necessary to try the best to collect sample of trachea excrete of the case. The diagnosis of Avian- human Influenza is not depend on whether Avian Influenza in fowl or not. Infection source, transmission route , and the influential factor of Avian - human Influenza would be assured in further study.