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血清HA、LN、CPⅢ和Ⅳ-C测定在160例肝纤维化患者诊断过程中的应用 被引量:1

Application of Determination of Serum Levels of Collagen TypeⅣ,Procollagen Type Ⅲ,Hyaluronic Acid and Laminin in Diagnosing Hepatic Fibrosis
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摘要 目的探讨慢性乙型病毒性肝炎血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(Ⅳ-C)在肝纤维化诊断中的应用价值。方法采用放射免疫分析法(R IA)检测160型慢性乙型病毒性患者血清HA、LN、PCⅢ和Ⅳ-C水平,并与肝组织活检纤维化程度进行相关性分析。结果各组慢性乙型病毒性肝炎患者血清HA、LN、PCⅢ和Ⅳ-C水平均高于正常对照组(p<0.05),与肝纤维化活动水平及程度呈密切正相关(p<0.01)。结论血清HA、LN、PCⅢ和Ⅳ-C水平能较好地反映乙型病毒性肝炎的慢性化程度和肝纤维化的活动水平及程度,联合检测可明显提高肝纤维化诊断的准确性和可靠性。 Objective To investigate the changes of serum levels of collagen type Ⅳ ( Ⅳ - C), procollagen type Ⅲ ( PC Ⅲ ), hyaluronie acid (HA) and their relationship with hepatic fibrosis in patients with chronic hepatitis B. Methods Serum levels of Ⅳ-C , PCⅢ, HA and LN were measured with hepatic radioimmunossay (RIA) in 160 patients with chronic hepatitis B of various types. The degree of hepatic fibrosis was ascertained with biopsy and correlationship with the corresponding levels of these 4 serum markers was studied. Resuits The levels of Ⅳ - C, PC Ⅲ , HA and LN in serum of patients with chronic hepatitis B of various types were higher than those of the control group. Serum levels of those markers were positively correlated with the degree of pathological changes of hepatic disease and the activity of hepatic fibrosis. Conclusion Serum levels of these markers could reflect the degree of hepatic fibrosis and severity of liver damage. Combined determination of those markers is a sensitive and reliable diagnostic method in diagnosing hepatic fibrosis.
出处 《川北医学院学报》 CAS 2006年第3期279-281,共3页 Journal of North Sichuan Medical College
关键词 透明质酸 层粘连蛋白 Ⅲ型前胶原 Ⅳ型胶原 慢性乙型病毒性肝炎 肝纤维化 HA LN PC Ⅲ Ⅳ -C Chronic hepatitis B Hepatic fibrosis
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