滋阴狼疮胶囊在系统性红斑狼疮激素撤减中的临床应用研究

Clinical Study of Ziyinglangchuang Capsule and Corticosteroid Withdrawal in Treating Systemic Lupin Erythematosus at Remission Stage

目的:观察以滋阴狼疮胶囊为主治疗系统性红斑狼疮(SLE)轻中度患者撤减糖皮质激素的疗效及对实验室指标的影响方法:选择SLE患者70例(治疗组40例、对照组30例),两组给予泼尼松治疗,初始量给予1mg/kg/d,对已服用激素的患者维持原用量,病情稳定7～14d后根据病情及激素减量法减量。治疗组加服滋阴狼疮胶囊,每次5粒,每天3次。结果:治疗组有效率为90%,略优于对照组(80%),显效率(45%)高于对照组(30%);在改善实验室指标(ESR、Hb等)方面,治疗组与对照组比较差异有显著性(P<0.01);治疗组的激素总用量(GC指数)明显低于对照组(P<0.05),治疗第4周开始治疗组激素日均用量小于对照组,治疗组激素撤减量明显大于对照组(P<0.05)。治疗组患者出现柯兴氏征、感染、胃肠道及精神神经症状等并发症少见,与对照组比较,差异有显著性和非常显著性意义(P<0.05,P<0.01)。结论:应用滋阴狼疮胶囊为主治疗轻中度SLE能较为顺利地消除症状,减少激素的用量及其引起的副作用,利于激素的撤减和病情的稳定。

Objective： To observe the therapeutic effect of Ziyinglangchaung capsule on corticosteroid withdrawal in patients with systemic lupus erythe-matosus（SLE） in remission stage and its influence on some experimental quality index. Methods.The SLE patients were divided into two groups,20 in the treated group and 20 in the control group,who were treated by conventional method with corticosteroids, and Ziyinglangchaung capsule was addedto the treated group. Results： TCM group is signficantly superior to the control group in the total effectiveness rate （90% of TCM group is higher than 80% of control group）. And its cure rate and apparent rate are both significantly higher than control group （P〈0.05）. The total corticorsteriods dosage of the TCM group is much smaller than that of the control group and the TCM group has the fewer dosage of in a day than the control group after 4 weeks. Its incidence rate of infection, diseases of digestive and nervous system is less than the control group, which is frequently caused by the west medicine. Conclusion： Using mainly Ziyinglangchaung capsule to treat SLE in remission stage could withdraw the corticosteroid smoothly, relieve symptoms and help to reducing dosage Of corticorsteriods and alleviating the side-effect of west medicine.