东北铁线莲对小鼠肿瘤的抑制作用

Anti-tumor effects of Clematis manshurica Rupr in mice

[目的]探讨东北铁线莲乙酸乙酯提取物的抗肿瘤作用.[方法]给小鼠接种S180肉瘤细胞制作S180肉瘤小鼠动物模型,随机分为空白对照组、东北铁线莲乙酸乙酯提取物大、中、小剂量组及环磷酰胺组,实验大、中、小剂量组分别给予0.8,0.4,0.2 g/kg东北铁线莲乙酸乙酯提取物,10 d后观察小鼠体重变化,计算肿瘤抑制率.[结果]东北铁线莲乙酸乙酯提取物大、中、小剂量组肿瘤抑制率分别为66.4%,55.3%,40.6%,与空白对照组比较有显著性差异.[结论]东北铁线莲乙酸乙酯提取物对小鼠S180肉瘤的生长具有抑制作用.

OBJECTIVE To study the anti-tumor effects of the ethyl acetate extraction of Clematis manshurica Rupr. METHODS The animal models were made by planting S180 sarcoma, and the models were randomly divided into control group, big, middle and small dosage of ethyl acetate extraction of Clematis manshurica Rupr group, cyclophosphamide group. The mice in experimental groups were given with 0.8, 0.4 and 0.2 g/kg dosages of the ethyl acetate extraction of Clematis manshurica Rupr respectively. After 10 days, changes of the tumor weight and body weight were studied. RESULTS The inhibitory rate of big, middle and small dosages of the ethyl acetate of Clematis manshurica Rupr group were 66.4%, 55.3%, and 40.6% , respectively, and there were significantly different from control group. CONCLUSION The ethyl acetate extraction of Clematis manshurica Rupr has remarkable inhibitory effects on S180 sarcoma in mice.