163例乙型肝炎患者血清前S1抗原检测意义

The significance of analysis of Pre S1 detection on 163 cases of hepatitis patients

[目的]探讨乙型肝炎病毒(HBV)前S 1抗原检测在乙型肝炎诊断中的意义.[方法]用ELISA法给163例不同类型乙型肝炎患者血清标本进行前S 1抗原检测,并进行HBV-DNA定量测定,分析性别及民族与前S 1抗原阳性的相关关系.[结果]大三阳患者前S 1抗原阳性率为95%,小三阳患者为51%;前S 1抗原阳性与HBV-DNA阳性相符率为95%.[结论]血清前S 1抗原检测对乙型肝炎诊断有意义.

OBJECTIVE To investigate diagnose value of Pre S 1 detection in patients with hepatitis B. METHODS Pre S 1 detection in the serum specimen of 163 cases of different type of hepatitis B were done by ELISA method, and the HBV-DNA were determined. The correlation relationship of sex, nationality and postive of pre S 1 were analysed. RESULTS The positive rate of PreS 1 was 95 % in the patients with HBsAg （＋）, HbeAg（ ＋ ）, HbcAb（ ＋ ）, and 51% in the correspond rate to the HBV-DNA appearance was value in patients with hepatitis B. patients with HbsAg（ ＋ ）, HbeAb（ ＋ ）, HbcAb（ ＋ ）, and The Pre S 1 detection has diagnose.