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肿瘤相关抗原MAGE-A3的研究进展 被引量：8

Advances in research of MAGE-A3
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摘要 肿瘤相关抗原MAGE-A3广泛表达于多种恶性肿瘤,而在正常组织中(除睾丸和胎盘外)不表达。该抗原经抗原递呈细胞加工后能被HLA I类或II类分子递呈,引起针对MAGE-A3表达阳性的肿瘤细胞的特异性免疫。近年来,MAGE-A3抗原已被广泛应用于肿瘤的诊断和免疫治疗,本文就MAGE-A3抗原在肿瘤中应用做一综述。 Melanoma-associated antigen MAGE-A3 is expressed in various types of tumors, but not in normal cells except testis and placenta. MAGE-A3 can be presented by both. HLA class Ⅰ and HLA class Ⅱ molecules after being processed into antigen peptide. MAGE-A3 has recently been widely used in the diagnosis and immunotherapy of tumors. This article reviews the applications of MAGE-A3 in the diagnosis and immunotherapy of tumors.
作者 黎皓 刘炳亚
机构地区 上海交通大学医学院附属瑞金医院肿瘤放化疗科上海消化外科研究所
出处 《中国癌症杂志》 CAS CSCD 2006年第7期599-601,共3页 China Oncology
关键词 MAGE-A3 肿瘤相关抗原 恶性肿瘤 诊断 免疫治疗 MAGE-A3 tumor associated antigen neoplasm diagnosis immunotherapy
分类号 R730.45 [医药卫生—肿瘤] R730.51 [医药卫生—肿瘤]
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参考文献20

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二级参考文献14

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共引文献17

同被引文献67

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二级引证文献14

中国癌症杂志
2006年 第7期

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