慢性系统疾病性贫血红细胞分布宽度分析

To Analyse Red Blood Cell Distribution Width of Anemia of Chronic Systemic Disease

目的:了解慢性系统疾病性贫血中肝性贫血、肾性贫血、糖尿病性贫血患者的红细胞分布宽度(RDW)的差异,探讨RDW的临床实验室辅助鉴别诊断价值。方法:用SysmexSF-3000全自动血细胞分析仪测定45例肝性贫血、45例肾性贫血和55例糖尿病性贫血患者的RDW值,比较三者RDW值的差异。同时设置45例门诊体检健康者作为正常对照。结果:肝性贫血患者的RDW值较正常对照组明显升高(P<0.01),肾性贫血患者的RDW值也较正常对照组高(P<0.05),糖尿病性贫血患者的RDW值与正常对照组差异无显著性(P>0.05)。不同慢性系统疾病性贫血男、女患者之间RDW值差异均无显著性(P>0.05)。中重度肝性贫血和糖尿病贫血患者RDW值高于轻度患者(P<0.01,P<0.05)。结论:RDW值的测定对临床鉴别此三种不同类别慢性系统疾病性贫血有一定的参考价值,对中度贫血以上糖尿病患者测定RDW值有临床意义。

Objective To explore the differences of red cell distribution width（RDW）among patients with anemia of chronic systemic disease involving hepatic anemia, renal anemia and diabetic anemia, and to determine the diagnosis value of RDW. Methods RDW values of 45 hepatic anemia,45 renal anemia and 55 diabetic anemia patients were measured by Sysmex SF-3000 hemocyte analyzer and were compared with each other. 45 healthy examiners were used as normal con- trols. Results The RDW values of hepatic anemia and renal anemia patients were obviously higher than those of normal controls（P〈0.01,P〈0. 05 respectively）, but the RDW values of diabetic anemia patients had not significant difference with those of normal controls（P〉0.05）. No significant differences could be found in the RDW values between male and female patients with the three different kinds of anemia（P〉0.05）. The RDW values of patients with mild hepatic anemia or diabetic anemia were significantly lower than those of the patients with moderate and severe patients（P〈0.01, P〈0.05）. Conclusion Detection of RDW value appeared a certain reference value to clinically identify the three different types of anemia of chronic systemic disease. For the patients with moderate diabetic anemia or above,RDW value determination was clinically significant.