期刊文献+

利用彗星分析法探讨氯乙烯聚合工人DNA损害 被引量:1

DETECTION OF DNA DAMAGE WITH COMET ASSAY IN POLYVINYL CHLORIDE WORKERS
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摘要 目的:探讨低浓度氯乙烯暴露(〈5ppm)和DNA伤害的相关性。方法:彗星分析法、Student's t-test和ANOVA检验。结果:在低浓度的氯乙烯暴露下(0.05-13.38ppm),仍然可以观察到在环境氯乙烯浓度大于1ppm的工人比小于1ppm的工人有较多的DNA单股断裂(P〈0.05)。结论:车间空气中氯乙烯的浓度即使达到法定容许浓度,仍可能对劳动者健康造成损害。 Objective: To determine the dose-response relationship between the low dcse exposure to Vinyl chloride monomer (VCM) and DNA damage remains unclear. Methods: Comet assay, Student's t - test and ANOVA test were used to assess the relationship. Results: The low dose exposure to VCM (0.05- 13.38 ppm) of )1 ppm can cause more DNA single-strand breaks than the exposure to that of〈 1 ppm. Conclusion: The results revealed that VCM may cause DNA damage at air levels below current TWA- PEL ( 10 ppm).
作者 熊文辉 杨倬
出处 《现代预防医学》 CAS 北大核心 2006年第7期1105-1106,1108,共3页 Modern Preventive Medicine
关键词 聚氯乙烯 彗星分析 DNA单股断裂 Polyvinyl chloride comet assay DNA single-strand breaks
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参考文献4

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同被引文献26

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