疏血通治疗脑梗死及其对血液流变学、内皮素的影响

Effect of Shuxuetong injection in treatment of cerebral infarction and on hemorheology and endothelin

目的:观察疏血通注射液治疗脑梗死的疗效及对血液流变学、内皮素的影响。方法:80例脑梗死患者,其中40例应用疏血通注射液6m l加生理盐水或5%的葡萄糖静滴,每日1次,14日为一个疗程。另外40例用血栓通10mL加入生理盐水或5%的葡萄糖静滴,每日1次,14日为一个疗程。治疗前后两组病例分别进行神经功能缺损评分(按第四届全国脑血管病学术会议通过的脑卒中患者临床神经功能缺损程度评分标准)、血液流变学、内皮素、肝、肾功能等指标检测。结果:疏血通组临床总有效率95.0%,对照组为80.0%。两组比较差异显著(x2=4.1143P<0.05)。治疗组血液流变学主要指标及血小板凝集率用药前后变化也有显著差异(P<0.01),治疗组治疗后血浆内皮素水平(49.55±6.18)ng/L较治疗前(63.86±5.72)ng/L和对照组治疗后(60.38±6.21)ng/L显著下降(t=10.7476,7.8181,P<0.01)。结论:疏血通注射液治疗脑梗死疗效良好,可以降低血液粘度,改善血液流变学,并能改善内皮细胞功能。

Objective：To observe the effect of Shuxuetong injection（疏血通注射液） in treatment of cerebral infarction（CI） and the effect to hemorheology and endothelin （ET）of patients with cerebral infarction. Methods：80 patients suffering from CI were randomly divided into 2 groups. In treatment group , 40 eases were treated with Shuxuetong injection 6ml ＋ 5% glucose 250ml intravenously drip, once a day, and 14days were as a therapeutic course . in control group , 40 eases were treated with Xueshuantong（血栓通） injection 10ml ＋ 5% glucose 250ml intravenously drip , also once a day and 14 days were as a therapeutic course . The curative effect of two groups was assessed before treatment and 14 days after treatment by The Clinical Standard on Stroke patient（ CSS）, established in the forth eerebrovaseular disease meeting of China in 1995. At the same time hemorheology and endothelin（ET） were observed. Results： The clinical effective percentage was 92.87% in treatment group , and it was 78.79% in control group. The difference between the 2 groups was significant （ x^2 = 4.1143 P 〈 0.05 ）. Fibrinogen, blood ＇viscosity , platelet aggregation were reduce after the treatment with Shuxuetong injection（ p〈0.01 ）. The level of ET（pg/mol） before treatment in treatment group and 14 days after treatment in two groups is （64.12± 5.59,49.34± 6.16, 59.56± 6.21 ）, respectively. The level of plasma ET decreased obviously after treatment in treatment group,and the difference was significant（ t =9. 6168,7. 1255 ,P〈0.01 ）. Conclusions： The Shuxuetong injection was effective to degrade the level of plasma FIB and ET, and improve the hemorheology and the function of endothelial cell. There is a great curative effect in the treatment of CI with Shuxuetong injection. And Intraeranial hemorrhage was not observed in treatment group .