血管紧张素Ⅱ1型受体基因A1166/C多态性与冠心病的关系

Association between angiotensin II type 1 receptor gene A1166/C polymorphism and coronary heart disease

目的探讨血管紧张素Ⅱ1型受体(AT1R)基因A1166/C多态性与冠心病(CHD)的关系。方法应用多聚酶链反应-限制性片段长度多态性(PCR-RELP)方法,测定109例冠心病患者及106名正常对照者的AT1R基因型。结果冠心病组与对照组之间AA、AC基因型频率和等位基因频率A、C比较差异无统计学意义(P>0.05)。冠心病组中发生心肌梗死者的AA、AC基因型频率和A、C等位基因频率与对照组比较差异无统计学意义(P>0.05)。冠心病组与对照组之间年龄、性别、既往史(高血压、高脂血症、糖尿病)、血糖、血脂、体重指数比较差异有统计学意义(P<0.05)。进行Logistic逐步回归分析,除高密度脂蛋白(OR<1,95%CI0.042～0.323)是保护因素外,其余各指标(OR>1)均为冠心病的危险因素。结论AT1R基因A1166/C多态性与冠心病可能无关联。

Objective To explore the association between angiotensin Ⅱ type 1 receptor gene （AT1R） polymorphism and coronary heart disease（CHD）. Methods By PCR-RELP methods,AT1R genotype of 109 CHD patients and 106 controls were detected. Results Neither the genotype frequencies of AA and AC nor the allele frequencies of A and C differ between the patients with CHD and the controls（P〉0.05 ）.Both the genotype frequencies of AA and AC and the allele frequencies of A and C did not differ between the patients with MI and the controls （P〉0.05）. The difference was statistically significant for age, gender,history （EH,high blood lipid,DM）,blood glucose,blood lipid and BMI between CHD and controls. Age,gender, smoking, EH, DM and HDL were indicated as effective variables in the Logistic regression model （P〈0.05）. Except HDL （OR 〈 1,95% CI 0.042 -0.323 ）was protector, the others （OR 〉 1 ）were danger factors of CHD. Conclusion No significant association between A1166/C polymorphism of AT1R gene and CHD is confirmed in this study.