高血压并发不同程度糖代谢异常血浆PAI-1水平变化

The association of plasminogen activator inhibitor-1 with the abnormality of glucose metabolism in patients with primary hypertension

目的探讨高血压患者并发不同程度糖代谢异常血浆纤溶酶原激活物抑制剂-1(PAI-1)的相关性及其影响。方法160例高血压病患者,根据空腹血糖(FPG)和OGTT检查2h血糖(2HPG)试验结果分为三组:糖耐量正常(NGT)组、糖耐量异常(IGT)组和糖尿病(DM)组。用酶联免疫双抗体吸附法(ELISA法)测定三组患者血浆PAI-1抗原。结果①单因素方差分析(ANOVA)显示,NGT、IGT和DM三组PAI-1水平差异有统计学意义[(30.25±6.17)ng/ml、(43.12±5.52)ng/ml和(55.04±8.03)ng/ml;P<0.01]。②以PAI-1与年龄、收缩压(SBP)、舒张压(DBP)、FPG、2HPG作直线回归分析,能进入该方程的变量为年龄、SBP、DBP、2HPG。结论高血压患者伴发糖代谢异常及其严重程度与PAI-1升高正相关;年龄、SBP、DBP、2HPG为PAI-1独立影响因素。

Objective To investigate the association between the plasminogen activator inhibitor-1 （PAI-1 ） and the abnormality of glucose metabolism in primary hypertensive patients. Methods According to the level of fast plasma glucose （FPG）and 2-hours- plasma-glucos （2HPG） of OGTT ,160 patients with primary hypertension were divided into 3 groups： normal glucose tolerance （NGT）, impaired glucose tolerity （IGT） and diabetes millitus （DM）.Plasma plasminogen activator inhibitor-1 （PAI-1） was measured by using Enzyme-link immunology sorbert assay （ELISA）. Results ①There were significant difference of the PAI-1 level among three groups [（30.25±6.17）ng/ml, （43.12±5.52）ng/ml, （55.04±8.03）ng/ml;P〈0.01 ].②Stepwise regression suggested that Age, SBP, DBP. 2HPG were independent variables of PAI-1.Conclusion The the abnormality of glucose metabolism in primary hypertension may induce PAI-1 increase, which is correlated with Age, SBP, DBP and 2HPG.