摘要
目的观察增补小柴胡汤联合拉米夫定治疗慢性乙肝对YMDD变异的影响。方法选择72例慢性乙型肝炎并均服用拉米夫定,其中治疗组36例患者服用拉米夫定的同时服用增补小柴胡汤,两组在治疗3、6、9、12个月时复查HBVDNA定量和YMDD变异。结果治疗组与对照组的HBVDNA阴转率比较无显著性差异(P=0.101>0.05);治疗组较对照组的YMDD变异阳性率显著下降P=0.036<0.05。结论增补小柴胡汤有明显抑制HBVDNA的YMDD变异作用。
Objective To explore the effect of lamivodine and Zengbu Xiao Chaihu. Decoction on YMDD mutation of chronic hepatitis B. Methods Seventy two patients of chronic hepatitis B were treated by lamivodine, in which 36 patients treated by Zengbu Xiao Chaihu Decoction at the same time. Both group were examined quantities of HBV DNA and YMDD mutation after 3,6,9,12 months. Results Negative ratio of HBV DNA between two groups had no significant difference. Positive ratio of YMDD mutation between two groups had significant difference. Conclusion Zengbu Xiao Chaihu Decoction had obvi- ous effect on reducing of YMDD mutation of HBV.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第3期249-250,共2页
Chinese Journal of Gastroenterology and Hepatology
关键词
慢性乙型肝炎
YMDD变异
中西医结合
Chronic Hepatitis B
YMDD mutation
Zengbu xiao chaihu Decocrtion