血清CA_(125)测定鉴别良恶性卵巢肿瘤的临床意义

Clinical significance of estimating blood serum CA125 for differential diagnosis of benign or malignant Ovarian Tumor

目的 探讨应用血清CA125测定来鉴别良、恶性卵巢肿瘤的临床意义。方法 采用进口CA125酶免试剂。以ELISA法对182例卵巢肿瘤的患者在剖腹探查前进行血清CA125测定，术后经组织病理学检查确诊。结果 49例卵巢癌中有40例（81．63％）血清CA125值显著升高（67～18345U／ml）；133例卵巢良性肿瘤中有27例血清CA125。值升高（65～216U／m1），两者差异有极显著性（P〈0．01）。结论 应用血清CA125测定来鉴别良、恶性卵巢肿瘤有重要意义。可作为诊断卵巢癌的敏感指标。

Objective The paper is concerned with clinical significance of estimating CA 125 in blood serum for differential diagnosis of benign or malignant ovarian tumor, Methods The concentration of CA 125 in blood serum was measured by ELISA in 182 patients with ovarian carcinoma which were definitely diagnosed from post-operation pathology detection of removal tissues, Import enzyme immunoreagent was adopted, Results 65 U/ml was used as critical value, among the 49 patients with ovarian tumor, CA 125 concen- trations in 40 of them did exceed significantly the normal level（67-18345 U/ml）, while in 27 from 133 patients with benign ovarian tumor CA 125 concentration increased to （65-216） U/ml, Significant statistical difference showed between the two groups（P〈0. 01）. Conclusion Estimating CA 125 in blood serum for differential diagnosis of benign or malignant ovarian tumor showed great clinical significance and proved to be a sensitive index for malignant ovarian tumor detection. But it seems that for patients of benign or malignant ovarian tumor patients with ascites, CA 125 concentration estimation was less meaningful.