某县注射吸毒人群HIV感染率和危险因素研究

HIV prevalence and risk factors of injection drug users in a county

目的 评估某县注射吸毒人群HIV感染率，探讨HIV感染相关的危险因素。方法 在某县戒毒所和社区征集满足条件的吸毒者，由经统一培训的调查员在单独的房间内进行访谈，同时采集血样进行HIV抗体检测。结果 调查注射吸毒人群269人，HIV感染率为26．0％（70／269）。在多因素非条件Logistic回归模型中，注射吸毒人群HIV感染有统计学意义。危险因素包括家庭所在地为县城（相对于其他乡镇）（OR=4．08，95％CI：1．65～10．08）、注射总次数≥1000次组（OR=7．45，95％CI：2．62～21．16）或注射总次数100～999次（OR=3．03，95％CI：1．04～8．86），在戒毒所内有共用针具行为（OR=8．32，95％CI：2．77～24．98）或仅有戒毒所外共用针具行为（OR=5．54，95％CI：1．97～15．60）。结论 目前该县注射吸毒人群HIV流行处于较高水平，需加强共用针具危险性的宣传教育，加强打击毒品隐蔽进入戒毒所的力度。

Objective To assess HIV prevalence and explore the risk factors of HIV infection among injection drug users in a county, Methods The subjects in compliance with the criterion were enrolled from drug center and community from Nov. 2003 to Mar. 2004. The trained investigators conducted the interview in a single room using a questionnaire. The blood samples were collected for HIV antibody test. Results 269 subjects were investigated. HIV prevalence of IDUs is 26. 0%（70/269）. Multivariate logistic regression showed that the independent risk factors of HIV infection among IDUs were （OR=4.08,95% CI： 1.65- 10.08）. Drug-injection was more than 1000 times （OR=7.45,95% CI：2.62-21.16） or between 100 and 999 times. （OR= 3, 03, ,95% CI：1.04--8.86）. Sharing needle in drug center （OR= 8.32,95% CI：2.77- 24.98） or sharing needle only outside the drug center was （OR= 5.54,95 % CI：I. 97-15, 60）, Conclusion In the investigated county HIV prevalence of IDUs was relatively high. Intervention should be carried out, including public education on the risk of sharing needle, and strengthening management of drug center to prohibit smuggling drug.