单克隆抗体与肿瘤细胞凋亡
摘要
单克隆抗体可通过多种作用机制治疗肿瘤,其中诱导肿瘤细胞凋亡是主要机制之一。不同的单克隆抗体可通过3种途径诱导肿瘤细胞凋亡:通过阻断生长因子及其受体信号传导途径影响肿瘤细胞的存活和生长,同时增强联合治疗中化疗或放疗的作用;通过使相应的抗原交联启动细胞凋亡途径;通过直接作用于死亡受体导致细胞凋亡。
出处
《国际肿瘤学杂志》
CAS
2006年第6期415-418,共4页
Journal of International Oncology
参考文献23
-
1Sclabas GM,Fujioka S,Schmidt C,et al.Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225.J Gastrointest Surg,2003,7(1):37-43.
-
2Harding J,Burtness B.Cetuximab:an epidermal growth factor receptor chemeric human-murine monoclonal antibody.Drugs Today (Barc),2005,41(2):107-127.
-
3Harari PM,Huang SM.Head and neck cancer as a clinical model for molecular targeting of therapy:combining EGFR blockade with radiation.Int J Radiat Oncol Biol Phys,2001,49(2):427-433.
-
4Huang ZQ,Buchsbaum DJ,Raisch KP,et al.Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody.J Surg Res,2003,111 (2):274-283.
-
5Nahta R,Hung MC,Esteva FJ.The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.Cancer Res,2004,64(7):2343-2346.
-
6Mohsin SK,Weiss HL,Gutierrez MC,et al.Neoadjuvant trastuzumab induces apoptosis in primary breast cancers.J Clin Oncol,2005,23 (11):2460-2468.
-
7Liang K,Lu Y,Jin W,et al.Sensitization of breast cancer cells to radiation by trastuzumab.Mol Cancer Ther,2003,2(11):1113-1120.
-
8Adams GP,Weiner LM.Monoclonal antibody therapy of cancer.Nat Biotechnol,2005,23 (9):1147-1157.
-
9Dias S,Hattori K,Heissig B,et al.Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.Proc Natl Acad Sci USA,2001,98(19):10857-10862.
-
10Fenton BM,Paoni SF,Ding I.Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors.Radiother Oncol,2004,72(2):221-230.
-
1郭英,邹启云,王丽.美罗华治疗B细胞淋巴瘤7例的观察及护理[J].中国误诊学杂志,2005,5(16):3175-3176. 被引量：7
-
2史晓宇(综述),周建华(审校).贝伐单抗治疗转移性结直肠癌[J].国际肿瘤学杂志,2008,35(3):209-211.
-
3黄炎,程丹,杨继元.胃肠道肿瘤的靶向治疗[J].国际肿瘤学杂志,2017,44(1):71-74.
-
4张红雨,陈红涛,彭培健.弥漫大B细胞淋巴瘤患者Bcl-2、p53和CD55表达与利妥昔单抗疗效的相关性研究[J].中华临床医师杂志（电子版）,2010,4(12):34-37. 被引量：2
-
5谢峥,万有才.贝伐珠单抗联合顺铂和局部放疗治疗晚期子宫颈腺癌的疗效观察[J].实用肿瘤杂志,2016,31(5):455-458. 被引量：2
-
6牛占恩,袁堂玲,李霞,徐胜军.美罗华联合化疗治疗非霍奇金淋巴瘤9例分析[J].中国误诊学杂志,2007,7(24):5923-5923.
-
7陆世丰,陆化.单克隆抗体治疗恶性血液病的研究进展[J].中国误诊学杂志,2008,8(6):1283-1285. 被引量：1
-
8张艳玲,王居峰,金钰萍.西妥昔单抗联合化疗治疗转移性结直肠癌28例的护理[J].中国误诊学杂志,2012,12(4):992-992. 被引量：3
-
9杨立平.曲妥珠单抗联合不同化疗药物治疗乳腺癌的临床疗效[J].医学临床研究,2015,32(8):1613-1616. 被引量：2
-
10耿一婷,李薇,殷咏梅.草酸铂与5-FU联合西妥昔单抗治疗结肠癌术后肠梗阻1例报道[J].实用肿瘤杂志,2010,25(6):689-689.
