2285例女性下生殖道人乳头状瘤病毒感染筛查结果分析

Analysis of the prevalence of human papillomavirus infection in the lower genital tract of 2285 women.

目的 探讨门诊就诊的高危人群人乳头状瘤病毒（HPV）感染的型别分布和年龄特征。方法 2004—10—2005-11采用核酸分子快速杂交分型技术，对2285例于北京大学第一医院妇产科门诊就诊妇女进行生殖道21种HPV亚型感染筛查。结果 HPV总感染率57．1％（1305／2285），21种型别均被检出，感染率最高的型别是HPV16，其他常见型别依次为58、52、53、33、6、CP8304、11、3l和18型，高危型感染41．0％，低危型7．2％，多型感染8．9％。2285例HPV感染高峰年龄在30～34岁（11．3％），40～44岁年龄段下降到7．6％，各年龄段HPV感染检出率差异有显著性意义（P〈0．01）。结论 门诊高危人群HPV感染率57．1％，常见型别为HPV16、58、52、53、33、6、CP8304、11、31和18型；人群感染高峰在30～34岁年龄段。

Objectives To screen the infection status of human papillomavirus （ HPV ） in outpatient women, Methods A total of 2285 outpatient women were checked for 21 HPV DNA types by DNA flow - through hybridization genotyping technique. Results All of the 21 types HPV were detected： the HPV - positive rate was 57.1% （1305/2285） ,and the overall prevalence of high - risk, low -risk and the multiplex HPV infection was 41,0% , 7.2% and 8, 9% , respectively. HPV 16 was the most common type,and the other common types, in descending order of frequency, were type 58, 52, 53, 33, 6, CP8304, 11, 31 and 18, The prevalence of HPV infection peaked in the 30 -34 years old （ 11,3% ） and then gradually declined, reaching a level of 7, 6% for women in the 40 ～ 44 years old. There was significant difference in the HPV - positive rates among each age group （P 〈 0. 01 ）, Conclusion Our study shows that the prevalence of HPV infection is 57.1% in outpatient women. The common types of HPV infection are 16, 58, 52, 53,33, 6, CP8304, 11, 31 and 18. The HPV infection peak age is 30 ～ 34 years old.