皮肤外用他克莫司治疗白癜风

Therapeutic Effect of Topical Taerolimus in Vitiligo Treatment

他克莫司是一种强效大环内酯类免疫抑制剂,随着其外用制剂的产生,越来越广泛地用于皮肤病的治疗,其中治疗特应性皮炎已较为成熟。在白癜风的治疗中也取得了一定的成效,且由于其局部不良反应小,耐受性高,有较好的应用前景,由于缺乏随机、双盲、对照的临床试验,他克莫司在白癜风治疗中与疾病类型的关系,是否还存在尚未发现的不良反应及长期使用系统吸收是否导致全身不良反应,仍需做进一步的研究。

Tacrolimus is a potent macrolide immunosupressant. With the development of topical preparation of tacrolimus, it is widely used in the treatment of skin diseases, and has been successfully used in atopic dermatitis. Also, because of its safety and high tolerance, it is expected to be used in vitiligo treatment. Since lack of randomized, double-blind and controlled clinical trials, large sample research is still required to investigate the relationship between the drug and clinical types of vitiligo, potential adverse reaction, systemic side effects due to long-term treatment, etc.