硬化萎缩性苔藓的研究进展

Advances in the Research of Lichen Sderosus et Atrophicus

硬化萎缩性苔藓是一种好发于外生殖器部位的慢性炎症性疾病,牵涉到临床许多不同学科。最近的研究显示硬化性萎缩性苔藓可能是一种与抗细胞外基质蛋白-1相关的自身免疫性疾病。临床表现为生殖器部位萎缩性白色斑块,因其被认为与外阴鳞癌有关,故有必要长期随访。硬化萎缩性苔藓的治疗常需要多学科的协作以使患者获得更好的临床疗效。

Lichen sclerosus et atrophicus （LS＆A） is a chronic inflammatory disease predominantly occurring in external genital area. Recently, studies indicate that LS＆A may be an autoimmune disease associated with extracellular matrix protein-1. The classic clinical picture is of atrophic white plaques in genital region. Due to the potential to progress into genital squamous cell carcinoma, long-term monitoring is required. A multidisciplinary approach has to be carried out for better therapeutic effect on LS＆A.