侵袭性曲霉病的治疗进展

Progress in the Treatment of Invasive Aspergillosis

曲霉病通常发生于免疫力低下的患者。严重侵袭性曲霉病可引起系统性感染,导敛死亡。曲霉病的治疗经过几十年的发展有了很大进展。新的抗真菌药物、免疫调节疗法和多种联合治疗方案的出现,使得侵袭性曲霉病患者的存活率有了显著提升。但在多种抗真菌药物的使用中出现的耐药现象也应该引起关注。

Aspergillosis usually occurs in immunocompromised population. Severe invasive aspergillosis can cause systemic infection, which may lead to death. After decades of development, obvious progress has been made in the treatment of aspergillosis. With the emergence of new antifungal agents, immunomodulation intervention and combination therapy, the survival rate of patients with invasive aspergillosis has been improved greatly. However, during the use of antifungal agents, more attention should be paid to the occurrence of drug resistance.