抗病毒药物西多福韦的合成研究

Synthesis of antiviral agent cidofovir

目的研究抗病毒药物西多福韦合成方法。方法以胞嘧啶为起始原料,经六步反应合成西多福韦。结果目标化合物总收率23.1%,结构经1H-NMR和MS确证,HPLC纯度在99%以上。结论用本法合成西多福韦,原料易得,操作简便,易于工业化生产。

Objective To synthesize an antiviral agent eidofovir. Methods Cidofovir was synthesized via 6-step reactions with cytosine as the starting material. Results The structure of eidofovir was verified by ^1H-NMR and MS. The purity of eidofovir determined by HPLC was higher Conclusion The simple synthetic procedure may be applied than 99.0%. The overall yield of eidofovir was 23. 1%. to a mass production scale.