丙戊酸钠对癫患儿瘦素及血脂的影响

Effect of Valproate on Leptin and Serum Lipids in Children with Epilepsy

目的研究丙戊酸钠(VPA)对癫患儿体质量指数(BMI)、瘦素及血脂的影响。方法选择准备单独服用VPA治疗的癫患儿24例,分别于治疗前、治疗后3、6个月观察BMI、瘦素、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的变化。结果VPA治疗3个月在BMI、瘦素、TC、TG、LDL-C均较治疗前明显升高(P均<0.05),HDL-C变化不明显。治疗6个月,其各项指标的变化基本同治疗3个月时,仅LDL-C又回降至治疗前水平。结论VPA有导致癫患儿肥胖的作用,且多在服用VPA3个月内发生,并对血脂有一定影响。

Objective To explore the effect of valproate（VPA） on body mass index（BMI）, leptin and serum lipids in children with epilepsy. Methods Twenty-four cases with epilepsy were selected. BMI and serum levels of leptin, total cholesterol（TC）, triacylglycerol（TG）, high density lipoprotein- cholesterin（HDL- C）, low density hipoprotein - cholesterin（LDL - C） after treated with VPA for 3 months and 6 months were determined. Results The levels of BMI,leptin,TC,TG, LDL - C after treated 3 months were all significantly higher than those of initial（all P 〈 0.05 ）. The change of HDL - C was not significant （ all P 〉 0.05 ）. Those in treated 6 months were same as levels of treated 3 months. Only LDL - C level was lower than that of 3 months and same as level of before treatment. Conelusion VPA do have efficacy to cause obesity in children with epilepsy, and most of the cases occur in the first 3 months after VPA treatment.