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胃癌患者EBV感染潜伏基因产物表达的研究 被引量：2

Study on gene products of EBV infection in castric carcinoma patients
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摘要 目的:研究EBV阳性胃癌中潜伏基因产物EBV编码的小RNA(EBER1)及潜伏膜蛋白LM P1的表达状况。方法:原位杂交法检测胃癌患者石蜡包埋组织标本中EBER1;免疫组化法检测EBV阳性胃癌中LM P1。结果:217例胃癌患者癌组织标本中检测到23例EBER 1;EBV阳性胃癌中无潜伏感染膜蛋白LM P1表达。结论:EBV阳性胃癌中缺乏潜伏感染膜蛋白LM P1的表达。 Objective：To investigate the expression of EBER1 and LMP1 in gastric carcinoma patients of EBV Infections . Methods： EBER1 in 217 cases of gastric carcinoma was detected with In Situ Hybridization . Then, EBV positive cases were selected for analysis of the expression level of LMP1 by immunohistochemistry. Results： In 217 cases of gastric carcinoma, there were EBER1 positive 23 cases; The expressiones of LMP1 in EBV positive gastric carcinoma were not detected. Conclusions： There was no LMP1 expression in EBV positive Gastric carcinoma.
作者 李淑英 朱丽华 夏庆安 周天戟
机构地区 华北煤炭医学院生物系 唐山市工人医院
出处 《陕西医学杂志》 CAS 北大核心 2006年第7期831-832,共2页 Shaanxi Medical Journal
基金 教育部留学回国人员科研基金资助(编号教外司留[2000]479)
关键词 胃肿瘤/免疫学 疱疹病毒科感染 基因表达 免疫组织化学 Stomach Neoplasma/immunology Herpesviridae Infections Gene Expression Immunohistochemistry
分类号 R733.4 [医药卫生—肿瘤] R735.2 [医药卫生—肿瘤]
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参考文献5

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二级参考文献24

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陕西医学杂志
2006年 第7期

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