婴儿健脾散的质量研究

Quality study of Yinger Jianpi San

目的建立婴儿健脾散中木香烃内酯、去氢木香内酯和碳酸氢钠含量的测定方法。方法高效液相色谱法测定木香烃内酯和去氢木香内酯的条件为:C18柱,流动相为甲醇-水(65∶35),UV检测波长为225nm;酸碱滴定法测定碳酸氢钠的含量。结果此方法可靠,稳定,平均回收率分别为98.75%,98.66%和98.94%,RSD分别为1.28%,1.51%和0.81%(n=6)。结论该方法测定灵敏,结果准确,可用于本品的质量控制。

OBJECTIVE To establish the method for determination of costunolide, dehydro-α-cureumene and sodium bicarbonate in Yinger Jianpi San. METHODS The HPLC method for costunolide and dehydro-α-eurcumene was used. Column：ODS-C18, mobile phase：methanol-water（65：35） ,UV wave length：225 nm;The acid-base titration for sodium bicarbonate was used. RESULTS This method was reliable and stable, The mean recovery was 98.75 %, 98.66% and 98.94%, RSD was 1.28%, 1.51% and 0.81% （ n = 6）. CONCLUSION The method developed is sensitive and accurate,and can be used for the quality control of Yinger Jianpi San.