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eIF3S10与肿瘤 被引量：1

eIF3S10 and tumor
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摘要 eIF3S10是真核细胞翻译起始因子eIF3最大的亚基,可与多个起始因子亚基相互作用,然而对于其具体的功能意义尚未完全阐明。最近的研究发现,eIF3S10在各肿瘤细胞株以及多种肿瘤,尤其是在各种肺癌组织中过度表达,认为其是细胞分化与增殖调节过程中重要的功能基因,其异常表达有可能在肿瘤发生发展和维持恶性表型的过程中发挥重要作用。 eIF3S10 is the biggest subunit of eIF3. The function of eIF3S10 is still undiscovered, although it can connect with a number of other eIFs. Some recent researches reported that eIF3S10 is overexpressed in cancer cells and cancer tissues, especially in lung cancers. It can be an important gene in cell differentiation and proliferation, and its overexpression may play an important role in tumor development and malignant phenotype maintenance.
作者 沈杰 谭渊明 刘昭前
机构地区 中南大学临床药理研究所
出处 《国际病理科学与临床杂志》 CAS 2006年第3期216-219,224,共5页 Journal of International Pathology and Clinical Medicine
关键词 翻译起始因子 eIF3S10 增殖 肿瘤发生 eukaryotic initiation factors elF3SIO proliferation tumorigenesis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献31

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  • 2Onda T,Uzawa K,Nakashima D,et al.Lin-7C/VELI3/MALS-3:an essential component in metastasis of human squamous cell carcinoma. Cancer Research . 2007
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国际病理科学与临床杂志
2006年 第3期

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