氨基末端脑钠尿肽激素原对小儿心功能的评估

Clinical value of amino-terminal pro brain natriuretic peptide in pediatric cardiology

氨基末端脑钠尿肽激素原现已被证实为成人充血性心力衰竭诊断、疗效监测、预后评估等的有效标志。它的血浆浓度同左室射血分数呈负相关,与临床心衰程度评分呈正相关。该文主要综述小儿氨基末端脑钠尿肽激素原的正常值范围及其对小儿心力衰竭或心功能不全的诊断、治疗监测等方面的最新进展。

Amino-terminal pro brain natriuretic peptide（NT-proBNP）, has been shown to be an effective indicator for diagnosis, therapeutic effect monitoring and prognosis assessment in adult congestive heart failure. NT-proBNP serum levels shown a negative correlation with the ejection fraction and a positive correlation with the clinical heart failure severity score. The purpose of this article is to review the current progress in study on the usefulness of NT-proBNP for diagnosis, monitoring and ventricular dysfunction. normal range of NT-proBNP in neonatal period and childhood, the predicting prognosis of children with congestive heart failure or left