SSRIs合并认知行为疗法治疗强迫症临床对照研究

Clinical Study of SSRI Combined with Cognitive Behavior Therapy on Obsessive Compulsive Disorder

目的:评价5-HT再摄取抑制剂(SSR Is)合并认知行为疗法对强迫症的治疗效果。方法:将符合CCMD-3诊断标准的57例强迫症患者随机分为治疗组和对照组,治疗组给予SSR Is合并认知行为治疗,对照组只给予SSR Is治疗。应用临床疗效标准及耶鲁布朗强迫量表(Y-BOCS)定期评定疗效,疗程6个月。结果:在治疗的第2个月末治疗组与对照组有显著性差别(P<0.05);4个月及6个月末治疗组与对照组有非常显著性差别(P<0.001),强迫性思维因子评分和强迫性行为因子评分在治疗第4及6个月末两组比较差别非常显著(P<0.001)。结论:SSR Is合并认知行为疗法治疗强迫症效果优于单独用SSR Is治疗。

Objective： To observe the efficacy of SSRI ＋ cognitive behavior therapy in patients with obsessive compulsive disorder （OCD）. Methods： 57 patients who met CCMD -3 for obsessive -compulsive disorder were assigned to therapeutic group （n = 29） and control group （ n = 28） . The therapeutic group were given SSRI ＋ cognitive behavior therapy for 6 months, the control group were given SSRI alone. The clinical effect was assessed with Y - BOCS at the on the 1st, 2nd, 4th and 6th month. Results： The efficacy of Therapeutic group were superior to the control group at the end of 2nd,4th and 6th month. Conclusions： The results suggest that SSRI combined with cognitive behavior therapy for obsessive compulsive disorder is more effective than SSRI alone in the clinic.