广东省野生动物接触人群SARS冠状病毒感染危险因素分析

Analysis of risk factors of SARS coronaryvirus infection among population contacted with wild animals in Guangdong Province

目的探索广东省特定人群野生动物接触与SARS冠状病毒感染的关系。方法采用ELISA法和间接免疫荧光试验(IFA)联合检测野生动物接触人群血清SARS冠状病毒IgG抗体(SARS-IgG),以判断SARS冠状病毒感染情况;用非条件logistic回归分析野生动物接触与SARS冠状病毒感染之间的关系。结果单因素非条件logistic回归分析结果表明,接触山猪、黄犭京、果子狸、蛇、穿山甲、巨蜥、猴和山鸡是SARS冠状病毒感染的可疑危险因素,OR值分别为5.81(P=0.000)、4.64(P=0.000)3、.31(P=0.000)、1.93(P=0.039)、12.98(P=0.029)、19.89(P=0.001)、11.05(P=0.001)和2.21(P=0.018);与非野生动物从业人员相比,从事野生动物销售、果子狸饲养和在经营野生动物酒家从事野生动物相关职业是SARS冠状病毒感染的可疑危险因素,OR值分别为31.55(P=0.001)、14.32(P=0.018)和8.14(P=0.043);多因素非条件logistic回归分析结果表明,接触山猪和果子狸是SARS冠状病毒感染的可疑危险因素,OR值分别为4.97(P=0.002)和2.95(P=0.022);与非野生动物从业人群相比,从事野生动物销售是SARS冠状病毒感染的可疑危险因素,OR值为31.99(P=0.004)。结论从事野生动物销售可能增加SARS冠状病毒感染机会;山猪和果子狸是广东省SARS冠状病毒感染的可能来源。

Objective To explore the correlation of SARS coronavirus（SARS COY）infection and the exposure of the population in GuangDong province to wiM animals. Methods ELISA AND IFAT were used for detection of IgG antibody to SARS COV and diagnosis of SARS COV infection. Unconditional logistic regression analysis was used in statistical analysis of the results. Results Univariate unconditional logistic regression analysis showed that exposure to wild boar, muntjac, civet cat, snake, pangolin, varanus, monkey and pheasant were suspected risk factors assoicated with SAP, S COV infection with OR 5.81 （ P = 0.000, OR95 % CI 3.07 - 10.99）,4.64 （P = 0.000,OR95%CI 2.10- 10.27）,3.31 （P = 0.000,OR95%CI 1.80-6.09）,1.93 （P =0.039,OR95%CI 1.05- 3.57）,12.98 （P =0.029, OR95%CI 1.33- 127.14）,19.89 （P = 0.001,OR95%CI 3.55- 111.40）,11.05 （P = 0. 001, OR95 % CI 2.98 - 41.01） and 2.21 （ P = 0.018 OR95 % CI 1.15 - 4.24）respectively. Compared with the population without exposed to wild animal, trading of wild animal, feeding of civet cat and working at hotels offering wild animal were suspected risk factors assoicated with SARS COV infection with OR 31.55 （ P = 0.001, OR95 % CI 4.23 - 233.23）, 14.32 （ P = 0. 018, OR95 % CI 1.59 - 129.24） and 8.14 （ P = 0.043, OR95 % CI 1.07 - 61.83） respectively. Multivariate unconditional logistic regression analysis indicated that exposure to wild boar and civet cat were suspected risk factors associated with SARS COV infection with OR 4.97 （ P = 0.002,OR95%CI 1.76 - 14.04）and 2.95 （P = 0.022,OR95% CI 1.20 - 7.28）as compared with population without exposed to wild animals; trading of wild animals was suspected risk factor asseiated with SAP, S COV infection, with OR 31.99 （P = 0.004, OR95%CI 3.11 - 328.31）. Conclusion Contacts with wild boar, muntjac, wite face civet cat, civet cat, snake, pangolin, varanus, monkey and pheasant , especially with wild boar and civet cat are suspected risk factors associated with of SARS COV infection in Guangdong Province. trading of wild animal, feeding of civet cat and service in hotel offering wild animal,especiaUy trading of wild animal, are suspected risk factors associated with SARS COV infection.